Motion in CD8 cytotoxic T cell co-receptor [cd8]
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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]
Structures 1AKJ Conformation 2 [ PartsList ] 1CD8 Conformation 1 [ PartsList ]
Description Protein motions play a crucial role in antibody-antigen interactions. In CD8, the T-cell cell-surface receptor, the alpha-3 domain reorientation is the only significant conformation change observed by Gao et al (1996) upon binding of HLA-A2 antigen by CD8. Changes focused at the pivotal point of the alpha-3 movement apparantly transmit conformational change from CD8 binding into the peptide-binding groove (and vice versa), although no such efect was apparent from the CD8 alpha-alpha/HLA-A2/peptide complex studied (see graphic).
Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19971130 Modification Date = 19971130
References Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen, BK [Medline info for 95086863]
Data and Graphics Graphic-1 Diagram depicting approximate positions of T-cell and antigen-presenting cell surfaces during binding, adapted from Gao et al., 1996.
GO terms associated with structures Molecular function MHC class I receptor activity Cellular component MHC class I protein complex Biological process antigen presentation
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu