Motion in Bacteriorhodopsin (bR) [br]

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Classification Suspected Fragment Motion, Shear Mechanism [F-s-2]

Structures
1BRD Conformation 1 [ PartsList ]
2BRD Conformation 1 [ PartsList ]

Description
This is a seven-helix transmembrane protein. In one intermediate in this cycle (M), movement is suspected in two helices (F and G). The seven transmembrane helices are packed around a chromophore. Light interacting with the chromophore drives the protein through a photocycle that pumps protons across the membrane. The major conformational changes in the photocycle involve small shifts in the position of two of the helices (F and G) relative to the others. Thus, the small sliding motions in bacteriorhodopsin, as well as that in the aspartate receptor, appear to be consistent with a shear mechanism.

Particular values describing motion
Creation Date = 19970822
Experimental Methods = e (Electron Diffraction)
Modification Date = 1999-08-23 13:06:58.000

References
R Henderson, J M Baldwin, T A Ceska, F Zemlin, E Beckmann and K H Downing (1990). Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J Mol Biol. 213: 899-929. [Medline info for 90294303]
S Subramaniam, M Gerstein, D Oesterhelt and R H Henderson (1993). Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin. EMBO J. 12: 1-8. [Medline info for 93154310]
S Subramaniam, M Gerstein, D Oesterhelt and R H Henderson (1993). Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin. EMBO J. 12: 1-8. [Medline info for 10074413]

GO terms associated with structures
Molecular functionion channel activity
Cellular componentmembrane
Biological procession transport

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Bacteriorhodopsin 1brd [ A ] 2brd [ A ] 246

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
20748-29491 Bacteriorhodopsin 1brd [ A ] 2brd [ A ] 246
35687-16320 Bacteriorhodopsin 1at9 [ A ] 2at9 [ A ] 246
603445-16463 Bacteriorhodopsin 1qm8 [ A ] 1dze [ A ] 248
603591-16747 Bacteriorhodopsin 1brd [ A ] 2brd [ A ] 246
038480-29975 bacteriorhodopsin 1brd [ B ] 2brd [ A ] 246
095421-1528 bacteriorhodopsin upload [ A ] upload [ A ] 196
501116-26899 brd upload [ A ] upload [ A ] 128
200379-12998 Native Conformation Of Bacteriorhodopsin 1fbb [ A ] 1fbk [ A ] 248


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu