Motion in Aspartate Receptor [aspr]
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Classification Known Subunit Motion, Not Involving Allostery [S-n-2]
Structures 1LIH Conformation 1 [ PartsList ] 2LIG Conformation 2 [ PartsList ]
Description Binding of Aspartate induces Helix 4A to move 1 A relative to Helix 1A. A smaller shearing motion also takes place between subunits 2 and 3 (2 goes with 1 and 3 goes with 4), and there is a hinge region between 2 and 3 that contains two prolines. A helix shift translation of up to 1.5 A and rotations of up to 5 degrees has been observed. Evidence suggests this motion is propagated through the membrane and is involved in signal transduction. The belief is that the propagation of motion through the membrane involves a piston-like motion of the the transmembrane helices (discussed in Lynch and Koshland below).
Particular values describing motion Creation Date = 19971130 Experimental Methods = x (Traditional x-ray) Maximum CA displacement (A) = 1.5 (from article) Maximum Rotation (degrees) = 5 (from article) Modification Date = 1999-07-27 14:13:50.000
References Chervitz SA, Falke JJ (1993). Molecular mechanism of transmembrane signaling by the aspartate receptor: a model. Proc Natl Acad Sci U S A 1996 Mar 1993(6):2545-2550. [Medline info for 96197350] Milburn MV, Prive GG, Milligan DL, Scott WG, Yeh J, Jancarik J, Koshland DE Jr, Kim SH (1991). Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand. Sci. 254(5036):1342-134 [Medline info for 92073901] Scott WG, Milligan DL, Milburn MV, Prive GG, Yeh J, Koshland DE Jr, Kim SH (1993). Refined structures of the ligand-binding domain of the aspartate receptor from Salmonella typhimurium. J Mol Biol 1993 Jul 20;232(2):555-573 [Medline info for 93347242] Lynch BA, Koshland DE Jr. Disulfide cross-linking studies of the transmembrane regions of the aspartate sensory receptor of Escherichia coli. Proc Natl Acad Sci U S A 1991 Dec 1;88(23):10402-6 [Medline info for 1660136]
Data and Graphics Graphic 1 Aspartate Receptor Graphics Pages (via Colorado)
GO terms associated with structures Molecular function signal transducer activity, transmembrane receptor activity Cellular component membrane Biological process chemotaxis, signal transduction
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu