Motion in Argininosuccinate synthetase [as]

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Classification [D-?-2]

Structures 1K92 1KP2 1KP3

Description Binding of ATP results in a large rigid body conformational change of the nucleotide binding domain.Several interrelated conformational changes, most important of which is the ATP induced change.

References Christopher T Lemke, P Lynne Howell (2002). Substrate induced conformational changes in argininosuccinate synthetase. J Biol Chem, 277:13074-81 [Medline info for 11809762] C T Lemke, P L Howell (2001). The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis. Structure (Camb), 9:1153-64 [Medline info for 11738042]

GO terms associated with structures Molecular function argininosuccinate synthase activity, ATP binding Biological process arginine biosynthesis

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu