Motion in Argininosuccinate synthetase [as]

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Classification [D-?-2]

Structures
1K92
1KP2
1KP3

Description
Binding of ATP results in a large rigid body conformational change of the nucleotide binding domain.Several interrelated conformational changes, most important of which is the ATP induced change.

References
Christopher T Lemke, P Lynne Howell (2002). Substrate induced conformational changes in argininosuccinate synthetase. J Biol Chem, 277:13074-81 [Medline info for 11809762]
C T Lemke, P L Howell (2001). The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis. Structure (Camb), 9:1153-64 [Medline info for 11738042]

GO terms associated with structures
Molecular functionargininosuccinate synthase activity, ATP binding
Biological processarginine biosynthesis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Argininosuccinate synthetase 1k92 [ A ] 1kp2 [ A ] 455

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
599162-24210 Argininosuccinate Synthetase 1k92 [ A ] 1kp2 [ A ] 455
072697-1409 Argininosuccinate Synthetase 1kp2 [ A ] 1kp3 [ A ] 455
313010-7627 Argininosuccinate Synthetase 1kp2 [ A ] 1k92 [ A ] 455


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu