Motion in Annexin V (Trp motion) [anxtrp]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures 1ANX Conformation 3 [ PartsList ] 1AVR Conformation 1 [ PartsList ] 2RAN Conformation 2 [ PartsList ]

Description Large movements of 2 loops and end of a helix moves a buried trp residue 18 Angstrom to surface. Function of motion is unclear but it appears to be related to calcium concentration. The same change is seen in comparing annexin I (1AIN) to annexin V.

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References N O Concha, J F Head, M A Kaetzel, J R Dedman and B A Seaton (1993). Rat Annexin V Crystal Structure: Ca2+-Induced Conformational Changes. Science. 261: 1321-1324. [Medline info for 93369587] J Sopkova, M Renouard and A Lewit-Bentley (1993). The Crystal Structure of a New High-calcium Form of Annexin V. J. Mol. Biol. 234: 816-825. [Medline info for 94076351]

GO terms associated with structures Molecular function calcium ion binding, calcium-dependent phospholipid binding

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu