Motion in Annexin V (breathing motion) [anxbreat]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures 1AVH Conformation 2 [ PartsList ] 1AVR Conformation 1 [ PartsList ]

Description Annexin V has four domains (1, 2, 3, and 4). Domains 1 and 2 can move relative to 3 and 4. The motion involves the rotation of a few degrees and occurs in varying amounts throughout all known annexin structures. The function is unknown.

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References R Huber, R Berendes, A Burger, M Schneider, A Karshikov, H Luecke, J Romisch and E Paques (1992). Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. J Mol Biol. 223: 683-704. [Medline info for 92177413]

GO terms associated with structures Molecular function calcium ion binding, calcium-dependent phospholipid binding

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu