Motion in Actin [actin]

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Classification Suspected Domain Motion, Shear Mechanism [D-s-1]

Structures
1ATN Conformation 1 [ PartsList ]

Description
Similar to hexokinase (XBAabx layering). The second reference describes the structural similarity of actin and the heat-shock protein.
Comparison of actin with hexokinase strongly suggests that actin may exist in an open form, in which the large and small domains wing apart as in hexokinase. Fiber diffraction studies described in reference three, in which the refined structure of actin was divided into four domains, should only small domain movements, except for domain two, which had to be moved approximately 6A to be consistent with the data.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
K C Holmes and W Kabsch (1991). Muscle proteins: actin. Current Opinion in Structural Biology 1:270-280. [Medline info for 9615437]
W Kabsch, H G Mannherz, D Suck, E F Pai and K C Holmes (1990). Atomic structure of the actin-DNase I complex. Nature. 347: 37-44. [Medline info for 9615437]
K M Flaherty, D B McKay, W Kabsch and K C Holmes (1991). Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein. Proc. Natl. Acad. Sci. USA. 88: 5041-5045. [Medline info for 9615437]

GO terms associated with structures
Molecular functiondeoxyribonuclease activity, motor activity, structural constituent of cytoskeleton, protein binding
Cellular componentactin filament
Biological processDNA catabolism


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu