Motion in Acetyl-CoA synthase [acs]

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Classification [D-h-2]

Structures
1OAO a2-B2 tetramer

Description
Alpha subunits in the asymmetric unit have significantly different conformations of the three domains relative to eachother.

References
Claudine Darnault, Anne Volbeda, Eun Jin Kim, Pierre Legrand, Xavier Vernède, Paul A Lindahl, Juan C Fontecilla-Camps (2003). Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase. Nat Struct Biol, 10:271-9 [Medline info for 12627225]

GO terms associated with structures
Molecular functionnickel ion binding, iron ion binding, oxidoreductase activity, carbon-monoxide dehydrogenase (acceptor) activity
Cellular componentcytoplasm
Biological processelectron transport, generation of precursor metabolites and energy, acetyl-CoA metabolism

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
acetyl-CoA-synthase upload [ A ] upload [ A ] 728



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu