Motion in Nicotinic Acetylcholine Receptor [achr]

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Classification Suspected Fragment Motion, Unclassifiable [F-?-1]

A motion of transmembrane helices is seen in low-resolution images of the nicotinic acetylcholine receptor (10). This gated ion channel has five subunits, and the channel is lined by a helix from each of them. Binding of acetylcholine ~35 A away from the membrane leads to substantial rearrangements that switch the channel-lining helices to an alternative association and open the channel.

Particular values describing motion
Creation Date = 19970822
Experimental Methods = e (Electron Diffraction)
Modification Date = 1999-08-23 13:15:01.000

Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL (2000). Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A Jan 18;97(2):623-628 [Medline info for 9615437]

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Email: Mark.Gerstein _at_