Motion in Cytochrome bc1 Complex, (Chicken Heart Mitochondria) [Cbc1_chicken]

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Classification Suspected Fragment Motion, Shear Mechanism [F-s-2]

Structures 1BCC Conformation 1 2BCC Conformation 2

Description The cytochrome bc1 complex is one of the three major respiratory enzyme complexes residing in the inner mitochondrial membrane. X-ray crystal structures of the cytochrome bc1 complex from chicken (in addition to cow and rabbit) reveal two different locations for the extrinsic domain of one component of the enzyme. These locations involve oxidation/reduction mechanisms that must involve movement of the extrinsic domain of the Fe-S component in order to shuttle electrons from ubiquinol to cytochrome c1.

Particular values describing motion Creation Date = 20050816 Experimental Methods = e (X-ray crystallography) Modification Date = 2005-08-16 13:06:58.000

References Z Zhang, L Huang, VM Shulmeister, YI Chi, KK Kim, LW Hung, AR Crofts, EA Berry, SH Kim (1998). Electron transfer by domain movement in cytochrome bc1. Nature 392(6677):677-684 [Medline info for 9565029]

GO terms associated with structures Molecular function electron transporter activity, heme binding, oxidoreductase activity, ubiquinol-cytochrome-c reductase activity Cellular component ubiquinol-cytochrome-c reductase complex (sensu Eukaryota), mitochondrial electron transport chain, membrane, ubiquinol-cytochrome-c reductase complex, mitochondrial membrane Biological process mitochondrial electron transport, ubiquinol to cytochrome c, electron transport

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu