Molecular Movements Database
This outline presents the current database classified by any classification scheme for which data has been compiled. The original schema which separates motions by type of movement is defined on the help page. Thumbnail images appear for motions which have available movies, and link to the best morph for that particular protein.Many more movies can be seen here, including structures not represented on this page. The movies page also allows searches for protein names or specific PDB IDs.
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I. Motions of Fragments Smaller than Domains
A. Motion is predominantly shear
F-s-2. Proteins for which two or more conformations are known Adenosylcobinamide Kinase [motion]   [morph] Small G-protein Arf6 [motion]   [morph] Bacteriorhodopsin (bR) [motion]   [morph] Calbindin [motion]   [morph] Dihydrofolate Reductase (DHFR) [motion]   [morph] Histidine-Containing Phosphocarrier Protein [motion]   [morph] Insulin [motion]   [morph] Signalling protein NtrC [motion]   [morph] Peroxisome proliferator-activated receptor - gamma [motion]   [morph] Rho RNA-binding domain [motion]   [morph] Ribonuclease [motion]   [morph] S100 Calcium sensor [motion]   [morph] Tetracycline repressor [motion]   [morph] Thymidylate Synthase [motion]   [morph]
F-s-1. Proteins for which only one conformation is known but motion is suspected
B. Motion is predominantly hinge
F-h-2. Proteins for which two or more conformations are known Annexin V (Trp motion) [motion]   [morph] Ap4A hydrolase [motion]   [morph] beta Lactoglobulin [motion]   [morph] Calcyclin [motion]   [morph] Cro repressor protein from lambda phage [motion]   [morph] Cystatin [motion]   [morph] Enolase [motion]   [morph] FecA transporter [motion]   [morph] Foot and mouth disease virus [fmdv] Glutamine Prpp amidotransferase [motion]   [morph] HIV-1 protease [motion]   [morph] Hhal Methyltransferase [motion]   [morph] Isocitrate Dehydrogenase (IDH) [motion]   [morph] Immunoglobulin (CDR motion) [igcdr] Lactate Dehydrogenase (LDH) [motion]   [morph] Lipase [motion]   [morph] Malate Dehydrogenase (MDH) [motion]   [morph] M. tuberculosis Antigen 85-C [motion]   [morph] Oprtase [motion]   [morph] Ran [motion]   [morph] Ras Protein [motion]   [morph] Seryl-tRNA synthetase [motion]   [morph] Taq DNA polymerase I [motion]   [morph] Triglyceride Lipase [motion]   [morph] Triose Phosphate Isomerase (TIM) [motion]   [morph] Yersinia Protein Tyrosine Phosphatase [motion]   [morph]
F-h-1. Proteins for which only one conformation is known but motion is suspected Chorismate Lyase Catalytic Cycle [cl]
C. Motion can not be fully classified at present
F-?-2. Proteins for which two or more conformations are known Cytochrome P-450CAM [motion]   [morph] Chemotaxis Receptor [motion]   [morph] CheY Protein [motion]   [morph] Estrogen receptor [motion]   [morph] Transcription regulator Fixj [motion]   [morph] Glutamine Synthetase [motion]   [morph] GroES mobile loop [motion]   [morph] Virus MS2 coat protein [ms2coat] Bacteriophage Pf1 coat protein [pf1coat] Motion of the Purine Repressor upon binding DNA [motion]   [morph] Photoactive Yellow Protein (PYP) [motion]   [morph] Ribosomal protein S15 [motion]   [morph] Stromelysin catalytic domain [motion]   [morph] Thaumatin [motion]   [morph] Tnf receptor-associated factor 6 (Traf6) [motion]   [morph]
F-?-1. Proteins for which only one conformation is known but motion is suspected Nicotinic Acetylcholine Receptor [achr] K channel [kchann]
D. Motion is not hinge or shear
F-n-2. Proteins for which two or more conformations are known Ribosomal protein L11 [motion]   [morph] Lac Repressor (Order-disorder transition of headpiece linker upon binding DNA) [motion]   [morph] Ubiquitin conjugating enzyme [motion]   [morph] MS2 Phage Coat Protein [motion]   [morph] OxyR transcription factor [motion]   [morph] Pin1 Peptidyl-Prolyl Cis-Trans Isomerase [motion]   [morph]
F-n-1. Proteins for which only one conformation is known but motion is suspected
II. Domain Motions
A. Motion is predominantly shear
D-s-2. Proteins for which two or more conformations are known Aspartate Amino Transferase (AAT) [motion]   [morph] Alcohol Dehydrogenase (ADH) [motion]   [morph] Anthrax Toxin Lethal Factor [motion]   [morph] Calpain protease core [motion]   [morph] Cytochrome P450BM-3 [motion]   [morph] Cholesterol oxidase [motion]   [morph] E. coli clamp loader gamma subunit [motion]   [morph] Citrate Synthase [motion]   [morph] Copper oxidase [motion]   [morph] Aspartic Proteases, besides endothiapepsin: Penicllopepsin, Rhizopuspepsin, Chymosin, Porcine Pepsin [motion]   [morph] Aspartyl tRNA Synthetase [motion]   [morph] EIAV Capsid Protein [motion]   [morph] Endothiapepsin [motion]   [morph] E. coli Enzyme I [motion]   [morph] E. coli Enzyme I [motion]   [morph] Glutamyl tRNA synthetase [motion]   [morph] Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) [motion]   [morph] Glycerol Kinase [motion]   [morph] Glutamate mutase [motion]   [morph] GM2-Activator (Human) [motion]   [morph] Tyrosine Kinase-Type Cell Surface Receptor Her2 [motion]   [morph] Hexokinase [motion]   [morph] Human Interluekin 5 [hil5] Kinesin-like KIF1A Motor Domain [motion]   [morph] Luciferase [motion]   [morph] Molybdate-binding protein Modg [motion]   [morph] E. Coli Mta/Adohcy Nucleosidase [motion]   [morph] Orotidine Monophosphate Decarboxylase [motion]   [morph] Phenylalanine Hydroxylase [motion]   [morph] Phosphofructokinase (PFK) (not allosteric transition) [motion]   [morph] DNA Polymerase III [motion]   [morph] Phosphoserine Phosphatase [motion]   [morph] PvuII endonuclease [motion]   [morph] SARS virus protease [motion]   [morph] Signal recognition particle GTPase Ffh [motion]   [morph] Trp Repressor (TrpR) [motion]   [morph] Threonine tRNA Synthetase [motion]   [morph]
D-s-1. Proteins for which only one conformation is known but motion is suspected Actin [actin] Heat Shock Protein (HSP) [hsp]
B. Motion is predominantly hinge
D-h-2. Proteins for which two or more conformations are known Acetylcholinesterase [motion]   [morph] Acetyl-CoA synthase [motion]   [morph] Adenylate Kinase (ADK) [motion]   [morph] Annexin V (breathing motion) [anxbreat] ATP Sulfurylase [motion]   [morph] Biotin carboxylase [motion]   [morph] Catabolite Gene Activator Protein (CAP) [motion]   [morph] CBL [motion]   [morph] Cell Adhesion Molecule CD2 [motion]   [morph] Glutamate Dehydrogenase (GDH) [motion]   [morph] Calmodulin [motion]   [morph] Cre Recombinase [motion]   [morph] c-Src tyrosine kinase [motion]   [morph] cyanovirin-N [motion]   [morph] C. Glutamicum DAP Dehydrogenase [motion]   [morph] Dehydroquinase Type II [motion]   [morph] DNA Beta-Glucosyltransferase [motion]   [morph] DnaK chaperone [motion]   [morph] Diphtheria Toxin (DT) [motion]   [morph] E. coli. Periplasmic Dipeptide Binding Protein [motion]   [morph] Elongation Factor 2 [motion]   [morph] Elongation Factor G [motion]   [morph] Family-5 Endoglucanase CelC [eg] 5-Enol-Pyruvylshikimate-3-Phosphate Synthase [motion]   [morph] Various Kinases (Tyr, Ser, Thr) [motion]   [morph] Formate Dehydrogenase (FDH) [motion]   [morph] Ferric binding protein [motion]   [morph] Fibronectin [motion]   [morph] Folylpolyglutamate Synthetase [motion]   [morph] Glutamine Binding Protein [motion]   [morph] Glycerate Dehydrogenase (GDH) [motion]   [morph] Guanylate Kinase (GDK) [motion]   [morph] Glucose ABC transporter ATPase subunit [motion]   [morph] Glur2 ligand-binding core [motion]   [morph] Glutamate Dehydrogenase [motion]   [morph] GroEL domain [motion]   [morph] Guanylate kinase [motion]   [morph] HCV Helicase [motion]   [morph] Hemagglutinin (Influenza) [motion]   [morph] 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase [motion]   [morph] Heat Shock Transcription Factor [motion]   [morph] Canine Lymphoma Immunoglobulin (Fc-Fab hinge) [ighinge] Influenza Matrix Protein M1 [motion]   [morph] Interferon-gamma [intfg] 3-Isopropylmalate Dehydrogenase [motion]   [morph] Iron Sulfur Protein; ubiquinol: cytochrome c oxidoreductase (bc1 complex) [motion]   [morph] Lysine/Arginine/Ornithine (LAO) binding protein [motion]   [morph] Lactoferrin [motion]   [morph] Leucocyte Immunoglobulin-Like Receptor-1 ligand binding domain [motion]   [morph] T4 lysozyme mutants: Ile3->Pro & Met6->Ile [motion]   [morph] Maltodextrin Binding Protein (MBP) [motion]   [morph] MMLV Reverse Transcriptase [motion]   [morph] mRNA capping enzyme [motion]   [morph] Methylene-Tetrahydromethanopterin Dehydrogenase [motion]   [morph] Mura (Udp-N-Acetylglucosamine Enolpyruvyltransferase) [motion]   [morph] Oligopeptide-binding protein [motion]   [morph] Phosphate-binding protein [motion]   [morph] Phosphoglycerate Kinase [motion]   [morph] cAMP-dependent Protein Kinase (catalytic domain) [motion]   [morph] DNA Polymerase Beta (Pol Beta) [motion]   [morph] Type-C Inorganic Pyrophosphatase [motion]   [morph] Pyruvate Kinase [motion]   [morph] Glutaminyl-tRNA synthase [motion]   [morph] Ribose Binding Protein [motion]   [morph] Recoverin [motion]   [morph] Thioredoxin reductase/Glutathione reductase [motion]   [morph] Eukaryotic RNA Polymerase [rnapol] Replication protein A DNA-binding domain [motion]   [morph] Ribose-5-Phosphate Isomerase [motion]   [morph] T7 Phage RNA Polymerase [motion]   [morph] Tomato Bushy Stunt Virus (TBSV) Coat Protein [motion]   [morph] Transferrins (N-terminal lobe) [motion]   [morph] Troponin-C [motion]   [morph] Tryptophan Synthase [motion]   [morph] Uracil-DNA Glycosylase [motion]   [morph]
D-h-1. Proteins for which only one conformation is known but motion is suspected Arabinose, Leucine, and Galactose Binding Proteins [abp] Porphobilinogen Deaminase [pda] Sulfate & Phosphate Binding Proteins [sbp] Trp RNA-binding attenuation protein [motion]   [morph]
C. Motion can not be fully classified at present
D-?-2. Proteins for which two or more conformations are known Anthrax Toxin Oedema Factor [motion]   [morph] Argininosuccinate synthetase [motion]   [morph] Adenylosuccinate Snythetase [motion]   [morph] CD8 cytotoxic T cell co-receptor [cd8] GTP Binding Protein [motion]   [morph] Yeast cell-cycle control protein p13suc1 and homan homologue CksHs [ckshs] Elongation Factor Tu (EF-Tu) [motion]   [morph] Gamma delta resolvase [motion]   [morph] Heterotrimeric G protein [gprot] Imidazole Glycerol Phosphate Sythase [motion]   [morph] Initiation factor 2 [motion]   [morph] Myosin [motion]   [morph] NF-kappa B [motion]   [morph] Serotonin N-Acetyltransferase [motion]   [morph] TATA-box Binding Protein (TBP) [motion]   [morph] Themolysin, Elastase, neutral proteases [thermo] Topoisomerase [motion]   [morph]
D-?-1. Proteins for which only one conformation is known but motion is suspected GCN4 [gcn4] Proteinaceous Infectious Particles (Prions) [prion] Transducin-a [tducin]
D. Motion is not hinge or shear
E. Motion involves partial refolding of tertiary structure
D-f-2. Proteins for which two or more conformations are known Bungarotoxin [motion]   [morph] G(i alpha 1) [motion]   [morph] S. aureus alpha-Hemolysin [motion]   [morph] Haemagglutinin [hglut] HIV-1 Reverse Transcriptase [motion]   [morph] Spindle Assembly Checkpoint Protein [motion]   [morph] Release Factor 2 [motion]   [morph] Serpins [motion]   [morph]
D-f-1. Proteins for which only one conformation is known but motion is suspected
III. Larger Movements than Domain Movements involving the Motion of Subunits
A. Motion involves an allosteric transition
S-a-2. Proteins for which two or more conformations are known Aspartate Transcarbamoylase (ATCase) [motion]   [morph] Erythropoietin (binding receptor) [motion]   [morph] Fructose-1,6-biphosphatase [motion]   [morph] Glycogen Phosphorylase (GP) [motion]   [morph] Hemoglobin (Hb) [motion]   [morph] Heparin Cofactor II [motion]   [morph] Lac Repressor Core (Allosteric Motion) [lacrallo] Lac Repressor upon binding DNA (Subunit motion via Tetramerization domain) [lacrdtet] Phosphofructokinase [motion]   [morph] Prpp synthetase [motion]   [morph] VirB11 ATPase (HP0525) [motion]   [morph]
S-a-1. Proteins for which only one conformation is known but motion is suspected Allosteric Motion in the Purine Repressor [purrallo]
B. Motion does not involves an allosteric transition
S-n-2. Proteins for which two or more conformations are known Alcohol Dehydrogenase Class II (Mouse) [motion]   [morph] ArsA ATPase [motion]   [morph] Aspartate Receptor [aspr] Bam HI Endonuclease [motion]   [morph] Immunoglobulin (VL-VH movement) [motion]   [morph] ATP-binding cassette protein MalK [motion]   [morph] S. cerevisiae PPR1 Zn-finger DNA recognition protein. [ppr1] Xrcc4 [motion]   [morph]
S-n-1. Proteins for which only one conformation is known but motion is suspected Erythropoietin Receptor [epr] F1-ATPase [f1atpase] Polymerase Processivity Factor PCNA [pcna] T7 DNA Helicasee [t7helicase]
C----. Complex Protein Motions Calcium ATPase pump [motion]   [morph] GroEL [motion]   [morph] PcrA DNA Helicase [motion]   [morph] Lac Repressor (Overall motion) [lacr] Na,K ATPase pump [nakpump] PI-SceI Endonuclease [motion]   [morph] Protein-like heteropolymer [plhp] DNA Polymerase from phage Rb69 [motion]   [morph] Topoisomerase type II [motion]   [morph]
V. Nucleic Acids